Laetril Tratment Info: 'Value Of Liver Cancer Screening Doubtful Says Danish Study'

Wednesday, June 20, 2012

'Value Of Liver Cancer Screening Doubtful Says Danish Study'

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Main Category: Liver Disease / Hepatitis
Also Included In: Alcohol / Addiction / Illegal Drugs; Cancer / Oncology; GastroIntestinal / Gastroenterology
Article Date: 20 Jun 2012 – 3:00 PDT

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A new study from Denmark finds that people with alcoholic cirrhosis are no more likely to die from liver cancer than other people, despite their having
a higher risk of the disease. The researchers conclude screening such patients is unlikely to save lives and would not be cost-effective.

Lead author Dr Peter Jepsen of Aarhus University Hospital and the University of Copenhagen, and colleagues, write about their findings in the June issue of
Annals of Internal Medicine.

Alcoholism can lead to cirrhosis or scarring of the liver, such that over time scar tissue replaces healthy tissue and prevents the liver from working properly. The
damage is permanent and irreversible and eventually leads to liver failure.

Jepsen and colleagues note that while some studies suggest people with alcoholic cirrhosis have a higher risk of developing liver cancer, and there is a belief
screening for the disease can reduce deaths in this population, this is not backed up by evidence from randomized trials because there haven’t been
any.

So he and his colleagues decided to investigate further by examining a nationwide Danish registry of patients who were admitted to hospital with a first-time
diagnosis of alcoholic cirrhosis between 1993 and 2005.

They found that of 8,482 patients diagnosed with alcoholic cirrhosis, 169 developed liver cancer and 5,734 died, 151 of whom had liver cancer.

But they found that the incidence of, and rate of death from, liver cancer was no greater among the alcoholic cirrhosis patients than in the general
population.

Jepsen and colleagues conclude that Danish patients with alcoholic cirrhosis have a low risk for liver cancer, and this disease has little impact on the high rate of
death in this group.

They note that a potential weakness of the study is that the diagnoses were made by hospital doctors without using a standard set of criteria, and because the
analysis used registry data only, there was no information on the clinical care of patients, for instance whether they had undergone screening for liver
cancer.

The researchers do not preclude the possibility that a randomized controlled study (comparing, for instance, alcoholic cirrhosis patients randomly assigned to
screening and non-screening) might find a different answer, but imply, that for the time being, this is the best answer from the data available.

Thus, on the basis of their findings, they suggest screening for liver cancer “would be expected to have a minimal effect on mortality and is unlikely to be cost-
effective”.

If there are no clear benefits, then the downsides of screening are heightened. For instance there is always a risk of a false positive, which can then lead to
further unnecessary and invasive tests.

In email correspondence with Reuters Health, Jepsen said ultrasound was often the preferred tool for initial liver cancer screening, and if that suggests there
could be a tumor present, the patient is referred for a CT scan, which carries the risk of radiation exposure.

Written by Catharine Paddock PhD

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Wednesday, June 20, 2012

'Value Of Liver Cancer Screening Doubtful Says Danish Study'

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